Cafe au lait macule - Kafe Au Lait Maculehttps://en.wikipedia.org/wiki/Café_au_lait_spot
Kafe Au Lait Macule (Cafe au lait macule) – tekis, giperpigmentatsiyalangan tug‘ilish belgisi.

Kafe au lait dog‘lari sog‘lom odamlarda ham uchraydi, lekin neyрофиброматоз 1‑toifa kabi sindromlar bilan bog‘liq bo‘lishi mumkin. Dog‘lar soni neyрофиброматоз tashxisi uchun klinik ahamiyatga ega bo‘lishi mumkin. Balog‘at yoshidan oldingi bolalarda kamida 5 mm diametrli olti yoki undan ortiq dog‘lar, balog‘atga etishgan shaxslarda esa kamida 15 mm diametrli dog‘lar neyрофиброматозning asosiy diagnostik mezonlaridan biridir.

Kafe au lait dog‘lari odatda tug‘ilishda paydo bo‘ladi, doimiy bo‘lib, vaqt o'tishi bilan hajmi kattalashi yoki soni ko‘payishi mumkin. Lazer operatsiyasidan keyin ham dog‘lar ko‘pincha butunlay olib tashlanmaydi yoki davolanishdan keyin yana paydo bo‘lishi mumkin.

Davolash
Qaytalanish darajasi odatda yuqori bo‘lib, lazer bilan davolash uzoq muddat talab etadi.
#QS1064 / QS532 laser
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  • Bir xil rangli chegaralar va aniq dog‘lar ko‘pincha bolalikda paydo bo‘ladi. Umuman olganda, bu rasmdagi chegaralar aniqroq ko‘rinadi.
  • Cafe au lait macule Neurofibromatosis type 1 (NF-1)da ko‘riladi.
References Laser treatment for Cafe-au-lait Macules: a systematic review and meta-analysis 37291616 
NIH
Lazer bilan davolash CALM bilan og‘rigan bemorlarning 75%ida 50% tozalash tezligini ko‘rsatdi, 43% esa 75% tozalash darajasiga erishdi. Turli xil lazer turlari orasida QS‑1064‑nm Nd:YAG eng samarali natijalarga erishdi. Umuman olganda, barcha lazer turlari kam yon ta’sirga ega edi, masalan, gipopigmentatsiya va giperpigmentatsiya, bu yaxshi xavfsizlikni ko‘rsatadi.
To draw a conclusion, the laser treatment could reach an overall clearance rate of 50% for 75% of the patients with CALMs, for 43.3% of the patients, the clearance rate could reach 75%. When looking at different wavelength subgroups, QS-1064-nm Nd:YAG laser exhibited the best treatment capability. Laser of all the wavelength subgroups presented acceptable safety regarding of the low occurrence of side effects, namely, hypopigmentation and hyperpigmentation.
 Cutaneous manifestations in neurofibromatosis type 1 32901776
Café-au-lait macules were shown in 1063 patients (96.5%), axillary and inguinal freckling in 991 (90%) and neurofibromas in 861 (78.1%). Other skin manifestations included: lipoma (6.2%), nevus anemicus (3.9%), psoriasis (3.4%), spilus nevus (3.2%), juvenile xanthogranuloma (3.2%), vitiligo (2.3%), Becker's nevus (1.9%), melanoma (0.7%) and poliosis (0.5%).
 Pigmentation Disorders: Diagnosis and Management 29431372
Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules.